Mass spectrometry for neurosurgery: Intraoperative support in decision‐making

SI Pekov, DS Bormotov, SI Bocharova… - Mass Spectrometry …, 2025 - Wiley Online Library
Ambient ionization mass spectrometry was proved to be a powerful tool for oncological
surgery. Still, it remains a translational technique on the way from laboratory to clinic. Brain …

Insight into new opportunities in intra-surgical diagnostics of brain tumors

J Bogusiewicz, B Bojko - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Brain tumor removal is a crucial step in therapeutic regimens. In surgical interventions, the
ultimate goal is to completely resect the malignant lesion with a safe margin of healthy …

Incorporation of a disposable ESI emitter into inline cartridge extraction mass spectrometry improves throughput and spectra stability

DS Bormotov, VA Eliferov, OV Peregudova… - Journal of the …, 2022 - ACS Publications
Rapid and reliable methods for detecting tumor margins are crucial for neuro-oncology.
Several mass spectrometry-based methods have been recently proposed to address this …

Rapid estimation of tumor cell percentage in brain tissue biopsy samples using inline cartridge extraction mass spectrometry

SI Pekov, DS Bormotov, PV Nikitin, AA Sorokin… - Analytical and …, 2021 - Springer
Tumor cell percentage (TCP) is an essential characteristic of biopsy samples that directly
affects the sensitivity of molecular testing in clinical practice. Apart from clarifying diagnoses …

Assessment of variation of inline cartridge extraction mass spectra

ES Zhvansky, VA Eliferov, AA Sorokin… - Journal of Mass …, 2021 - Wiley Online Library
Recently, mass‐spectrometry methods show its utility in tumor boundary location. The effect
of differences between research and clinical protocols such as low‐and high‐resolution …

Analysis of phosphatidylcholines alterations in human glioblastomas ex vivo

SI Pekov, AA Sorokin, AA Kuzin, KV Bocharov… - … ), Supplement Series B …, 2021 - Springer
The analysis of data obtained using ambient mass spectrometric profiling of clinical samples
of primary and secondary human glioblastomas ex vivo, revealed changes in the lipid …

Aggregation of Multimodal ICE-MS Data into Joint Classifier Increases Quality of Brain Cancer Tissue Classification

AA Sorokin, DS Bormotov, DS Zavorotnyuk, VA Eliferov… - Data, 2022 - mdpi.com
Mass spectrometry fingerprinting combined with multidimensional data analysis has been
proposed in surgery to determine if a biopsy sample is a tumor. In the specific case of brain …

Lipid Profiles of Human Brain Tumors Obtained by High-Resolution Negative Mode Ambient Mass Spectrometry

DS Zavorotnyuk, SI Pekov, AA Sorokin, DS Bormotov… - Data, 2021 - mdpi.com
Alterations in cell metabolism, including changes in lipid composition occurring during
malignancy, are well characterized for various tumor types. However, a significant part of …

The lightweight spherical samplers for simplified collection, storage, and ambient ionization of drugs from saliva and blood

MA Shamraeva, SI Pekov, DS Bormotov, RE Levin… - Acta Astronautica, 2022 - Elsevier
The continuous monitoring of health conditions before, during, and after spaceflight is an
important task in gravitational physiology. Thus a simple, non-invasive method for biological …

Comparison of Dimensionality Reduction Methods in Mass Spectra of Astrocytoma and Glioblastoma Tissues

E Zhvansky, A Sorokin, V Shurkhay… - Mass …, 2021 - jstage.jst.go.jp
Recently developed methods of ambient ionization allow the collection of mass
spectrometric datasets for biological and medical applications at an unprecedented pace …