Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …

Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

Burns are among the most common causes of trauma worldwide. Reducing the healing time
of deep burn wounds has always been a major challenge. Traditional dressings not only …

Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …

Animal models have provided invaluable information in the pursuit of medical knowledge
and alleviation of human suffering. The foundations of our basic understanding of disease …

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes
to the development of pain hypersensitivity. How activated microglia selectively enhance the …

Laboratory Animal Anaesthesia, Fourth Edition provides a basic guide to anaesthesia for a
very diverse audience needing content, with straight-forward, structured style of writing …