Abstract Glycoprotein (GP) VI (GPVI) plays a major role in thrombosis but not haemostasis,
making it a promising antithrombotic target. The primary role of GPVI on the surface of …

Honokiol (HNK) is a natural polyphenolic compound extracted from the bark and leaves of
Magnolia grandiflora. It has been traditionally used as a medicinal compound to treat …

Thrombus, bacterial infections, and severe inflammation are still serious problems that have
to be faced with blood-contacting materials. However, it is a great challenge to …

Background Collagen-induced platelet activation is predominantly mediated by glycoprotein
(GP) VI through formation of receptor clusters that coincide with the accumulation of …

Introduction: Diindolylmethane (DIM), a major acid condensation product of Indole-3-
carbinol, is known to inhibit platelet aggregation and thrombosis. The drugs with antiplatelet …

Diindolylmethane (DIM), a major metabolite of indole-3-carbinol (I3C), plays a vital role in
the pharmacological actions of I3C. The role of DIM in the inhibition of platelet aggregation …

Objective: Current antiplatelet medications increase the risk of bleeding, which leads to a
clear clinical need in develo** novel mechanism-based antiplatelet drugs. TYMP …

Cardiovascular disease, in particular due to arterial thrombosis, is a leading cause of
mortality and morbidity, with crucial roles of platelets in thrombus formation. For multiple …

Acute coronary syndromes (ACS) are a global cause of mortality and morbidity that affect
millions of lives worldwide. Following atherosclerotic plaque rupture, platelet activation and …

Cerebral amyloid angiopathy (CAA) and β-amyloid (Aβ) deposition in the brain parenchyma
are hallmarks of Alzheimer's disease (AD). We previously reported that platelets contribute …