Supramolecular helical systems: helical assemblies of small molecules, foldamers, and polymers with chiral amplification and their functions

E Yashima, N Ousaka, D Taura, K Shimomura… - Chemical …, 2016 - ACS Publications
In this review, we describe the recent advances in supramolecular helical assemblies
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …

Aromatic amide foldamers: structures, properties, and functions

DW Zhang, X Zhao, JL Hou, ZT Li - Chemical reviews, 2012 - ACS Publications
The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

Synthetic foldamers

G Guichard, I Huc - Chemical Communications, 2011 - pubs.rsc.org
Foldamers are artificial folded molecular architectures inspired by the structures and
functions of biopolymers. This highlight focuses on important developments concerning …

A field guide to foldamers

DJ Hill, MJ Mio, RB Prince, TS Hughes… - Chemical …, 2001 - ACS Publications
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

β-Peptides: from structure to function

RP Cheng, SH Gellman, WF DeGrado - Chemical reviews, 2001 - ACS Publications
In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Synthetic helical polymers: conformation and function

T Nakano, Y Okamoto - Chemical Reviews, 2001 - ACS Publications
The high functionalities of naturally occurring macromolecules such as proteins and genes
arise from their precisely ordered stereostructures. 1 In such systems, the helix is often found …

Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose

N Chandramouli, Y Ferrand, G Lautrette… - Nature Chemistry, 2015 - nature.com
The ab initio design of synthetic molecular receptors for a specific biomolecular guest
remains an elusive objective, particularly for targets such as monosaccharides, which have …

Aromatic oligoamide foldamers

I Huc - European Journal of Organic Chemistry, 2004 - Wiley Online Library
Aromatic oligoamide foldamers possess a high potential for mimicking the secondary
structures of biopolymers. These oligomers are efficiently designed, easy to synthesize, and …

Therapeutic potential of foldamers: from chemical biology tools to drug candidates?

R Gopalakrishnan, AI Frolov, L Knerr… - Journal of Medicinal …, 2016 - ACS Publications
Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …

Aromatic δ-peptides

H Jiang, JM Léger, I Huc - Journal of the American Chemical …, 2003 - ACS Publications
Oligoamides of 8-amino-2-carboxy-quinoline adopt a very stable helical conformation
characterized in solution by 1H NMR and in the solid state by single-crystal X-ray diffraction …