The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Here we present a guide to ion mobility mass spectrometry experiments, which covers both
linear and nonlinear methods: what is measured, how the measurements are done, and how …

Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the
endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy …

Understanding the composition, structure and stability of larger synthetic molecules is crucial
for their design, yet currently the analytical tools commonly used do not always provide this …

In this Review, we focus on an important aspect of ion mobility (IM) research, namely, the
reporting of quantitative ion mobility measurements in the form of the gas-phase collision …

Despite the growing importance of the mass spectrometry of membrane proteins, it is not
known how their transfer from solution into vacuum affects their stability and structure. To …

Ion mobility mass spectrometry (IM-MS) allows separation of native protein ions into
“conformational families”. Increasing the IM resolving power should allow finer structural …

The global dimensions and amplitudes of conformational fluctuations of intrinsically
disordered proteins are governed, in part, by the linear segregation versus clustering of …

Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite
multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to …