The mycobacterial cell envelope—a moving target
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …
The status of tuberculosis vaccine development
LK Schrager, J Vekemens, N Drager… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
CG Winchell, SK Nyquist, MC Chao, P Maiello… - Journal of Experimental …, 2023 - rupress.org
The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
Mycobacterium tuberculosis continues to cause devastating levels of mortality due to
tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the …
tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the …
The cellular architecture of the antimicrobial response network in human leprosy granulomas
Granulomas are complex cellular structures composed predominantly of macrophages and
lymphocytes that function to contain and kill invading pathogens. Here, we investigated the …
lymphocytes that function to contain and kill invading pathogens. Here, we investigated the …
Recent advancement, immune responses, and mechanism of action of various vaccines against intracellular bacterial infections
Emerging and re-emerging bacterial infections are a serious threat to human and animal
health. Extracellular bacteria are free-living, while facultative intracellular bacteria replicate …
health. Extracellular bacteria are free-living, while facultative intracellular bacteria replicate …
Human cytomegalovirus expands a CD8+ T cell population with loss of BCL11B expression and gain of NK cell identity
CD8+ T cells not only are critical mediators of adaptive immunity but also may exhibit innate-
like properties such as surface expression of NKG2C, an activating receptor typically …
like properties such as surface expression of NKG2C, an activating receptor typically …
Tuberculosis vaccines: Opportunities and challenges
B Zhu, HM Dockrell, THM Ottenhoff, TG Evans… - …, 2018 - Wiley Online Library
Tuberculosis (TB) is a serious disease around the world. Bacillus Calmette–Guérin (BCG) is
the only TB vaccine licensed for use in human beings, and is effective in protecting infants …
the only TB vaccine licensed for use in human beings, and is effective in protecting infants …
QuantiFERON TB Gold Plus for the diagnosis of tuberculosis: a systematic review and meta-analysis
Estimated 2017 tuberculosis (TB) incidence is 10 million and mainly depends on the
reservoir of individuals with latent TB infection (LTBI). QuantiferonⓇ-TB Gold in-Tube (QFT …
reservoir of individuals with latent TB infection (LTBI). QuantiferonⓇ-TB Gold in-Tube (QFT …
Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis
J Turner, JB Torrelles - Pathogens and disease, 2018 - academic.oup.com
Abstract Mannose-capped lipoarabinomannan (ManLAM), present in all members of the
Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high …
Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high …