Biologists have long been intrigued by the possibility that cells can change their identity, a
phenomenon known as cellular plasticity. The discovery that terminally differentiated cells …

Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

Regenerative abilities vary dramatically across animals. Even amongst planarian flatworms,
well-known for complete regeneration from tiny body fragments, some species have …

Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

Abstract DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester) is a γ-
secretase inhibitor that indirectly blocks the activity of Notch pathway. It is a potential …

In contrast to most well-studied model organisms, planarians have a remarkable ability to
completely regenerate a functional nervous system from a pluripotent stem cell population …

Regeneration of lost tissues depends on the precise interpretation of molecular signals that
control and coordinate the onset of proliferation, cellular differentiation and cell death …

Neoblasts are adult stem cells (ASCs) in planarians that sustain cell replacement during
homeostasis and regeneration of any missing tissue. While numerous studies have …

Planarians have a long history in the fields of developmental and regenerative biology.
These animals have also sparked interest in neuroscience due to their neuroanatomy …