The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

R Gheorghita, I Soldanescu, A Lobiuc… - Frontiers in …, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been
defined as the greatest global health and socioeconomic crisis of modern times. While most …

Large-scale phenoty** of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

F Liew, C Efstathiou, S Fontanella, M Richardson… - Nature …, 2024 - nature.com
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …

[HTML][HTML] Develo** effective strategies to optimize physical activity and cardiorespiratory fitness in the long Covid population-The need for caution and objective …

MA Faghy, R Duncan, E Hume, L Gough… - Progress in …, 2024 - Elsevier
Abstract The Post Covid-19 Condition (commonly known as Long Covid) has been defined
by the World Health Organisation as occurring in individuals with a history of probable or …

Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19

C Li, W Qian, X Wei, H Narasimhan, Y Wu… - Science translational …, 2024 - science.org
Postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection (PASC) represent an urgent public health challenge and are estimated to affect …

Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model

CS Schreiber, I Wiesweg, S Stanelle-Bertram, S Beck… - …, 2024 - thelancet.com
Summary Background Coronavirus disease 2019 (COVID-19) frequently leads to
neurological complications after recovery from acute infection, with higher prevalence in …

Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study

Y Zhao, Q Liang, Z Jiang, H Mei, N Zeng… - The Lancet Regional …, 2024 - thelancet.com
Background A variety of symptoms, particularly cognitive, psychiatric and neurological
symptoms, may persist for a long time among individuals recovering from COVID-19 …

Cohort profile: post-hospitalisation COVID-19 (PHOSP-COVID) study

O Elneima, HJC McAuley, OC Leavy… - International Journal …, 2024 - academic.oup.com
To date, there have been> 750 million reported cases of COVID-19 globally since the
pandemic began in early 2020. 1 In the UK, there have been> 1 million patients hospitalized …

Characteristics and determinants of pulmonary long COVID

MJ Patton, D Benson, SW Robison, D Raval… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
BACKGROUND Persistent cough and dyspnea are prominent features of postacute
sequelae of SARS-CoV-2 (also termed “long COVID”); however, physiologic measures and …

1H and 31P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID

LEM Finnigan, MP Cassar, M Jafarpour, A Sultana… - Radiology, 2024 - pubs.rsna.org
Background Emerging evidence suggests mitochondrial dysfunction may play a role in the
fatigue experienced by individuals with post–COVID-19 condition (PCC), commonly called …

[HTML][HTML] Children and young people with long COVID—comparing those seen in post-COVID services with a non-hospitalised national cohort: a descriptive study

F Newlands, AL Goddings, M Juste, H Boyd… - Children, 2023 - mdpi.com
Background: Post-COVID services have been set up in England to treat children with
ongoing symptoms of Long COVID. To date, the characteristics of children seeking treatment …