Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Methicillin-resistant Staphylococcus aureus (MRSA) is becoming dangerous to human
beings due to easy transmission mode and leading to the difficult-to-treat situation. The rapid …

Due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to
conventional antibiotics, further efforts are needed to develop new antimicrobial agents …

COVID-19 and associated substantial inflammations continue to threaten humankind
triggering death worldwide. So, the development of new effective antiviral and anti …

Rapid emergence of multidrug resistant Staphylococcus aureus infections has created a
critical health menace universally. Resistance to all the available chemotherapeutics has …

In a quest to innovate biologically active molecules, the benzoylation of 4, 6-
dimethylpyrimidine-2-thiol hydrochloride (1) with benzoyl chloride derivatives was employed …

Replacement of the n-butylphenyl moiety in the lipophilic part of the previously reported
arylthiazole antibiotics with naphthyl ring amended its activity against vancomycin resistant …

Candida species are a leading source of healthcare infections globally. The limited number
of antifungal drugs combined with the isolation of Candida species, namely C. albicans and …

Microbiological DNA gyrase is recognized as an exceptional microbial target for the
innovative development of low-resistant and more effective antimicrobial drugs. Hence, we …