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CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Migraine: a review on its history, global epidemiology, risk factors, and comorbidities
Migraine affects more than one billion individuals each year across the world, and is one of
the most common neurologic disorders, with a high prevalence and morbidity, especially …
the most common neurologic disorders, with a high prevalence and morbidity, especially …
CGRP and the trigeminal system in migraine
S Iyengar, KW Johnson, MH Ossipov… - … : The Journal of Head …, 2019 - Wiley Online Library
Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
[HTML][HTML] Pathophysiology of migraine: a disorder of sensory processing
Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …
more than one billion patients having an attack in any year, migraine stands as the sixth …
Migraine and sleep disorders: a systematic review
C Tiseo, A Vacca, A Felbush, T Filimonova… - The journal of headache …, 2020 - Springer
Migraine and sleep disorders are common and often burdensome chronic conditions with a
high prevalence in the general population, and with considerable socio-economic impact …
high prevalence in the general population, and with considerable socio-economic impact …
Applying a biopsychosocial model to migraine: rationale and clinical implications
C Rosignoli, R Ornello, A Onofri, V Caponnetto… - The journal of headache …, 2022 - Springer
Migraine is a complex condition in which genetic predisposition interacts with other
biological and environmental factors determining its course. A hyperresponsive brain cortex …
biological and environmental factors determining its course. A hyperresponsive brain cortex …
The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine
S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …
Comparison of new pharmacologic agents with triptans for treatment of migraine: a systematic review and meta-analysis
Importance New therapeutic classes of migraine-specific treatment have been developed,
including 5-hydroxytryptamine 1F receptor agonists (lasmiditan) and calcitonin gene-related …
including 5-hydroxytryptamine 1F receptor agonists (lasmiditan) and calcitonin gene-related …
The association between migraine and physical exercise
Background There is an unmet need of pharmacological and non-pharmacological
treatment options for migraine patients. Exercise can be used in the treatment of several …
treatment options for migraine patients. Exercise can be used in the treatment of several …
Calcitonin gene-related peptide (CGRP): a new target for migraine
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …