Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

Parkinson's disease is a progressive neurodegenerative disease characterized by tremor
and bradykinesia and is a common neurologic ailment. Male sex and advancing age are …

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor
deficits that are resistant to currently available therapies. To alleviate these deficits, we …

Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Cell replacement therapies for neurodegenerative disease have focused on transplantation
of the cell types affected by the pathological process. Here we describe an alternative …

Freezing of gait is a common and disabling symptom in patients with parkinsonism,
characterised by sudden and brief episodes of inability to produce effective forward …

Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of
Parkinson's disease, medically intractable essential tremor, and complicated segmental and …

Objectives To assess the feasibility and clinical efficacy of local field potentials (LFPs)–
based adaptive deep brain stimulation (aDBS) in patients with advanced Parkinson disease …

During the last 30 years, deep brain stimulation (DBS) has evolved into the clinical standard
of care as a highly effective treatment for advanced Parkinson's disease. Careful patient …

Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but
experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait …