O-GlcNAcylation—the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to
cytoplasmic, nuclear and mitochondrial proteins—is a post-translational modification that …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …

Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …

Recent advances in the understanding of the molecular mechanisms underlying cancer
progression have led to the development of novel therapeutic targeting strategies. Aberrant …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl
glucosamine (GlcNAc) to myriad cellular proteins. In response to nutritional and hormonal …

Pancreatic adenocarcinoma is a lethal disease with a 5‑year survival rate of< 5%, the lowest
of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue …