The removal of cells by apoptosis is an essential process regulating tissue homeostasis.
Cancer cells acquire the ability to circumvent apoptosis and survive in an unphysiological …

Despite elaborate characterization of the risk factors, bladder cancer is still a major
epidemiological problem whose incidence continues to rise each year. Urothelial carcinoma …

Background Ovarian cancer is a complicated malady associated with cancer stem cells
(CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year …

Nuclear factor kappa-B (NF-κB) activation is a common phenomenon in cancers, which
results in the aberrant expression of NF-κB target genes and leads to malignant …

Background Constitutive activation of signal transducer and activator of transcription 3
(Stat3) signaling pathway plays an important role in several human cancers. Activation of …

Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in
bladder tumors, little information is available on their specific effects in urothelial cells or the …

Bladder cancer is associated with high recurrence and mortality rates. These tumors show
vast heterogeneity reflected by diverse morphologic manifestations and various molecular …

Purpose This study sought to determine if alterations in molecular pathways could
supplement TNM staging to more accurately predict clinical outcome in patients with …

Objective: To evaluate the mRNA expression ratio of Bcl-2/Bax both in normal and tumoral
bladder tissues of patients with transitional cell carcinoma (TCC) of bladder and investigate …

Bladder cancer is the seventh most common malignancy worldwide, with almost 14,000
patients dying from this disease in the USA alone. Because of the need for long-term and …