The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Lactate was implicated in the activation of hepatic stellate cells (HSCs). However, the
mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Fluorescent probes have emerged as indispensable chemical tools to the field of chemical
biology and medicine. The ability to detect intracellular species and monitor physiological …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The increase of lactate is an independent risk factor for patients with sepsis-induced acute
kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its …

Lactate has been observed to fuel TCA cycle and is associated with cancer progression in
human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate …

Autophagy and glycolysis are highly conserved biological processes involved in both
physiological and pathological cellular programs, but the interplay between these processes …

Despite its central importance in cellular metabolism, many details remain to be determined
regarding subcellular lactate metabolism and its regulation in physiology and disease, as …