Peptides and proteins are naturally chiral molecular systems so that sensing their structure
and conformation with chirality-based spectral methods is an obvious and long-used …

Chiroptical spectroscopy exploring the interaction of matter with polarized light provides
many tools for molecular structure and interaction studies. Here, some recent discoveries …

Vibrational optical activity (VOA) refers to two vibrational techniques: vibrational circular
dichroism (VCD) and Raman optical activity (ROA) that are sensitive both to the chirality and …

Tau is an intrinsically disordered protein (IDP) implicated in Alzheimer's disease. Recently,
tau proteins were discovered to be able to catalyze self-acetylation, which may promote its …

Raman optical activity (ROA) is a relatively new method combining the variability of
scattering experiments with the structural sensitivity of chiral spectroscopy. Typically, ROA …

Amyloid fibrils are supramolecular systems showing distinct chirality at different levels of
their complex multilayered architectures. Due to the regular long‐range chiral organization …

Experiments suggested that the fibrillation of the 11–25 fragment (hIAPP (11–25)) of human
islet amyloid polypeptide (hIAPP or amylin) involves the formation of transient α-helical …

The Raman optical activity (ROA) spectroscopic technique has been applied in the past to
many biologically relevant systems including peptides, proteins, sugars, and even viruses …

We have compared the protein profiles in plaques and tangles in the hippocampus of post-
mortem Alzheimer brains and in opaque and clear regions in the deep cortex of eye lenses …

Alpha‐synuclein (α‐syn) is a 140 residue protein that plays a central role in Parkinson's
disease and other neurological disorders. The precise function and pathological properties …