Past, present and future perspectives in nonalcoholic fatty liver disease

AJ Sanyal - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) was first described as a distinct clinical entity four
decades ago. However, the condition has become the centre of attention within hepatology …

[HTML][HTML] Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis

S Leoni, F Tovoli, L Napoli, I Serio, S Ferri… - World journal of …, 2018 - ncbi.nlm.nih.gov
The current epidemic of non-alcoholic fatty liver disease (NAFLD) is resha** the field of
hepatology all around the world. The widespread diffusion of metabolic risk factors such as …

[HTML][HTML] Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

H Gao, Z **, G Bandyopadhyay, G Wang, D Zhang… - Cell metabolism, 2022 - cell.com
Hepatocytes have important roles in liver iron homeostasis, abnormalities in which are
tightly associated with liver steatosis and fibrosis. Here, we show that non-alcoholic fatty liver …

The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases

N Chalasani, Z Younossi, JE Lavine, M Charlton… - Hepatology, 2018 - journals.lww.com
This guidance provides a data‐supported approach to the diagnostic, therapeutic, and
preventive aspects of nonalcoholic fatty liver disease (NAFLD) care. A “Guidance” document …

Update on NAFLD genetics: from new variants to the clinic

E Trépo, L Valenti - Journal of hepatology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Molecular pathways of nonalcoholic fatty liver disease development and progression

F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

New trends on obesity and NAFLD in Asia

JG Fan, SU Kim, VWS Wong - Journal of hepatology, 2017 - Elsevier
Traditionally, obesity and its related diseases have been considered a problem in Western
countries. However, in the past two decades, urbanisation in many Asian countries has led …

Pathophysiology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

V Manne, P Handa, KV Kowdley - Clinics in liver disease, 2018 - liver.theclinics.com
The pathophysiology of NAFL and NASH is complex and numerous intermediaries are
involved. Each year brings new and exciting developments as pieces of the …

Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis

S Spahis, E Delvin, JM Borys, E Levy - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Nonalcoholic fatty liver disease (NAFLD), characterized by liver triacylglycerol
build-up, has been growing in the global world in concert with the raised prevalence of …