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Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Liquid–liquid phase separation in tumor biology
X Tong, R Tang, J Xu, W Wang, Y Zhao, X Yu… - Signal Transduction and …, 2022 - nature.com
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
MobiDB: 10 years of intrinsically disordered proteins
The MobiDB database (URL: https://mobidb. org/) is a knowledge base of intrinsically
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …
ELM—the Eukaryotic Linear Motif resource—2024 update
Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …
modular eukaryotic proteins. They are also the most abundant, especially when considering …
[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
[HTML][HTML] The molecular language of membraneless organelles
Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …
membrane-bound or membraneless. A large number of membraneless organelles, including …
It's not just a phase: function and characteristics of RNA-binding proteins in phase separation
Biomolecular condensates that form via phase separation are increasingly regarded as
coordinators of cellular reactions that regulate a wide variety of biological phenomena …
coordinators of cellular reactions that regulate a wide variety of biological phenomena …
MobiDB: intrinsically disordered proteins in 2021
The MobiDB database (URL: https://mobidb. org/) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …
intrinsically disordered proteins. Here, we report recent developments implemented in …
[HTML][HTML] The control centers of biomolecular phase separation: how membrane surfaces, PTMs, and active processes regulate condensation
Biomolecular condensation is emerging as an essential process for cellular
compartmentalization. The formation of biomolecular condensates can be driven by liquid …
compartmentalization. The formation of biomolecular condensates can be driven by liquid …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …