Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY **ang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y **e, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

[HTML][HTML] The β-secretase BACE1 in Alzheimer's disease

H Hampel, R Vassar, B De Strooper, J Hardy… - Biological …, 2021 - Elsevier
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β …

The role of microRNAs in neurodegenerative diseases: a review

S Li, Z Lei, T Sun - Cell biology and toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

MicroRNA delivery through nanoparticles

SWL Lee, C Paoletti, M Campisi, T Osaki… - Journal of Controlled …, 2019 - Elsevier
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …

RNA: the unsuspected conductor in the orchestra of macromolecular crowding

E Zacco, L Broglia, M Kurihara, M Monti… - Chemical …, 2024 - ACS Publications
This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Systematic review of miRNA as biomarkers in Alzheimer's disease

S Swarbrick, N Wragg, S Ghosh, A Stolzing - Molecular neurobiology, 2019 - Springer
Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …