Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family
resemble the classically-described System A and System N transport activities in terms of …

Glutamine is an essential nutrient for cancer cell proliferation, especially in the context of
citric acid cycle anaplerosis. In this manuscript we present results that collectively …

Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption
is upregulated relative to healthy cells. This metabolic reprogramming often depends upon …

Cancer cells require a robust supply of reduced nitrogen to produce nucleotides, non-
essential amino acids and a high cellular redox activity. Glutamine provides a major …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …

Glutamine is a multifaceted amino acid that plays key roles in many metabolic pathways and
also fulfils essential signaling functions. Although classified as non-essential, recent …

Cancer cells develop and succeed by shifting to different metabolic programs compared with
their normal cell counterparts. One of the classical hallmarks of cancer cells is their higher …

Neuroinflammation is the inflammatory responses that are involved in the pathogenesis of
most neurological disorders. Glutaminase (GLS) is the enzyme that catalyzes the hydrolysis …