Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …

Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Two monoclonal antibodies (mAbs), aducanumab and lecanemab, have received
accelerated approval from the US FDA for initiation of treatment in early Alzheimer's disease …

Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies
to prevent and treat AD remain elusive despite major efforts to understand its basic biology …

The function of B cells in Alzheimer's disease (AD) is not fully understood. While
immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and …

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …