Key events in mitosis such as sister chromatid separation and subsequent inactivation of
cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events …

Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks).
Phosphorylation of specific targets by cyclin–Cdk complexes sets in motion different …

To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and
conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase …

The adaptive responses of a living cell to internal and external signals are controlled by
networks of proteins whose interactions are so complex that the functional integration of the …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New
techniques, including the application of small-molecule inhibitors, have greatly expanded …

▪ Abstract Completion of the cell cycle requires the temporal and spatial coordination of
chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding …

The ability of cells to make exact replicas of themselves is central to the life and
development of complex organisms. Initial insights into the question of how cells divide …

The final stages of mitosis begin in anaphase, when the mitotic spindle segregates the
duplicated chromosomes. Mitotic exit is then completed by disassembly of the spindle and …