Inflammation and immune dysfunction in Parkinson disease
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …
organs as well as the central nervous system and involves a fundamental role of …
Parkinson's disease genetics and pathophysiology
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Common variant genome-wide association studies (GWASs) have, to date, identified> 24
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …
The genetics of Parkinson's disease and implications for clinical practice
JO Day, S Mullin - Genes, 2021 - mdpi.com
The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
Mitochondrial dysfunction in Parkinson's disease: new mechanistic insights and therapeutic perspectives
Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …
Parkinson's disease: from pathogenesis to pharmacogenomics
R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
Mitophagy in human diseases
L Doblado, C Lueck, C Rey, AK Samhan-Arias… - International journal of …, 2021 - mdpi.com
Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease
Mutations in the glucocerebrosidase gene (GBA), which cause Gaucher disease, are also
potent risk factors for Parkinson's disease. We examined whether a genetic burden of …
potent risk factors for Parkinson's disease. We examined whether a genetic burden of …
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …
Efficient Bayesian mixed-model analysis increases association power in large cohorts
Linear mixed models are a powerful statistical tool for identifying genetic associations and
avoiding confounding. However, existing methods are computationally intractable in large …
avoiding confounding. However, existing methods are computationally intractable in large …