As a key molecule of life, Deoxyribo-Nucleic Acid (DNA) is the focus of numbers of
investigations with the help of biological, chemical and physical techniques. From a physical …

Hybridization chain reaction (HCR) was a significant discovery for the development of
nanoscale materials and devices. One key challenge for HCR is the vulnerability to …

Here, we introduced the concept of strand exchange amplification (SEA) mediated by
denaturation bubbles. Similar to traditional PCR, it only employed a DNA polymerase and a …

Amplification reactions coupled with electrophoresis or real-time fluorescence system have
been successfully used for the analysis of nucleic acid. However, complex procedures or …

A statistical method is developed to estimate the maximum amplitude of the base pair
fluctuations in a three dimensional mesoscopic model for nucleic acids. The base pair …

The propensity of short DNA sequences to convert to the circular form is studied by a
mesoscopic Hamiltonian method which incorporates both the bending of the molecule axis …

The base pair fluctuations and helix untwisting are examined for a circular molecule. A
realistic mesoscopic model including twisting degrees of freedom and bending of the …

The flexibility of short DNA fragments is studied by a Hamiltonian model which treats the
inter-strand and intra-strand forces at the level of the base pair. The elastic response of a set …

Physicochemical properties of DNA, such as shape, affect protein-DNA recognition.
However, the properties of DNA that are most relevant for predicting the binding sites of …

The thermodynamic properties of DNA circular molecules are investigated by a new path
integral computational method which treats in the real space the fundamental forces …