Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …
[HTML][HTML] Natural phytochemicals as SIRT activators—focus on potential biochemical mechanisms
M Wiciński, J Erdmann, A Nowacka, O Kuźmiński… - Nutrients, 2023 - mdpi.com
Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …
VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis
P Xu, B Lin, X Deng, K Huang, Y Zhang… - Free Radical Biology and …, 2022 - Elsevier
Ferroptosis plays an essential role in the pathology of osteoporosis. This study investigated
whether vitamin D receptor (VDR) activation could protect against age-related osteoporosis …
whether vitamin D receptor (VDR) activation could protect against age-related osteoporosis …
[HTML][HTML] Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: the role of the ERK-CREB pathway and Bnip3-mediated mitophagy
Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic
fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating …
fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating …
Mitochondrial quality control and its role in osteoporosis
Mitochondria are important organelles that provide cellular energy and play a vital role in
cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly …
cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly …
Nutrient element decorated polyetheretherketone implants steer mitochondrial dynamics for boosted diabetic osseointegration
As a chronic metabolic disease, diabetes mellitus (DM) creates a hyperglycemic micromilieu
around implants, resulting inthe high complication and failure rate of implantation because …
around implants, resulting inthe high complication and failure rate of implantation because …
SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury
T **n, C Lu - Aging (Albany NY), 2020 - pmc.ncbi.nlm.nih.gov
Sirtuin-3 (SirT3) and AMPK stimulate mitochondrial biogenesis, which increases
mitochondrial turnover and cardiomyocyte regeneration. We studied the effects of SirT3 …
mitochondrial turnover and cardiomyocyte regeneration. We studied the effects of SirT3 …
[HTML][HTML] The implication of reactive oxygen species and antioxidants in knee osteoarthritis
Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential
challenge for public health, with a negative impact on the geriatric patient's quality of life …
challenge for public health, with a negative impact on the geriatric patient's quality of life …
Insights into oxidative stress in bone tissue and novel challenges for biomaterials
Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …
Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway
X Deng, B Lin, F Wang, P Xu, N Wang - Phytomedicine, 2024 - Elsevier
Background Ferroptosis is a crucial contributor to impaired osteoblast function in
osteoporosis. Mangiferin, a xanthonoid glucoside isolated from mangoes, exhibits anti …
osteoporosis. Mangiferin, a xanthonoid glucoside isolated from mangoes, exhibits anti …