Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …

The significant increase in the use of antifungal agents, both for the treatment of candidiasis
and invasive aspergillosis and as azole fungicides in agricultural crop protection has …

Infections due to Aspergillus species are an acute threat to human health; members of the
Aspergillus section Fumigati are the most frequently occurring agents, but depending on the …

Drug resistance in fungal pathogens is of incredible importance to global health, yet the
mechanisms of drug action remain only loosely defined. Antifungal compounds have been …

Invasive fungal infections (IFI) are important complications of cancer, and they have become
a major cause of morbidity and mortality in cancer patients. Effective anti-infection therapy is …

The polyene antifungal amphotericin B (AmB) exerts a powerful and broad activity against a
vast array of fungi and in general displays a remarkably low rate of antimicrobial resistance …

The polyene amphotericin B (AMB) exerts a powerful and broad antifungal activity. AMB acts
by (i) binding to ergosterol, leading to pore formation at the fungal plasma membrane with …

The emergence of resistant Aspergillus spp. is increasing worldwide. Long-term
susceptibility surveillance for clinically isolated Aspergillus spp. strains is warranted for …

Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line
triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified …

Aspergillus terreus is an emerging fungal pathogen in immunocompromised patients. Due to
the intrinsic resistance of AmB against A. terreus and acquiring resistance to azoles, an …