Simple Summary Oncolytic viruses (OVs) are viruses that selectively target and kill cancer
cells while sparing normal ones. OVs are from diverse families of viruses, but naturally …

In view of the advancement in the understanding about the most diverse types of cancer and
consequently a relentless search for a cure and increased survival rates of cancer patients …

Cytotoxicity of tumor-specific T cells requires tumor cell-to-T cell contact-dependent
induction of classic tumor cell apoptosis and pyroptosis. However, this may not trigger …

Purpose: We hypothesized that the combination of a local stimulus for activating tumor-
specific T cells and an anti-immunosuppressant would improve treatment of gliomas. Virally …

Solid cancers that metastasize to the lungs represent a major therapeutic challenge. Current
treatment paradigms for lung metastases consist of radiation therapy, chemotherapies, and …

Current standard treatments of cancer can prolong survival of many cancer patients but
usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic …

Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have
recently passed the randomized Phase III clinical trial hurdle. Both wild-type and engineered …

Introduction: Over the last decade, advances in biological therapies have resulted in
remarkable clinical responses for the treatment of some previously incurable cancers …

Pancreatic ductal adenocarcinoma (PDAC) is the major type of pancreatic malignancy with
very poor prognosis. Despite the promising results of immune checkpoint inhibitors (ICIs) in …

Many common neoplasms are still noncurative with current standards of cancer therapy.
More therapeutic modalities need to be developed to significantly prolong the lives of …