Many biological functions of peptides are mediated through G protein-coupled receptors
(GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the …

Oxidative deamination of dopamine produces the highly toxic aldehyde 3, 4-
dihydroxyphenylacetaldehyde (DOPAL), enhanced production of which is found in post …

Bioorthogonal chemistry enables a specific moiety in a complex biomolecule to be
selectively modified in the presence of many reactive functional groups and other cellular …

Work from our laboratories over the last 35 years that has focused on Ste2p, a G protein-
coupled receptor (GPCR), and its tridecapeptide ligand α-factor is reviewed. Our work …

The N-terminal part of the calcium-regulated and phospholipid-binding protein annexin AI
contains peptide sequences with pro-and anti-inflammatory activities. We have earlier …

In this paper we report here a hydrogen/deuterium exchange (H/D exchange) of cross-
linkable α-amino acid derivatives with deuterated trifluoromethanesulfonic acid (TfOD). H/D …

We describe a rapid method to probe for mutations in cell surface ligand-binding proteins
that affect the environment of bound ligand. The method uses fluorescence-activated cell …

Merrifield chemistry enables the convenient synthesis of oligonucleotides and peptides,
while recombinant DNA technology has facilitated protein engineering. Recently, protein …

Fundamental knowledge about how G protein-coupled receptors and their ligands interact is
important for understanding receptor-ligand binding and the development of new drug …

Ste2p, a G protein-coupled receptor (GPCR), binds α-factor, WHWLQLKPGQPMY, a
tridecapeptide pheromone secreted by yeast cells. Upon α-factor binding, Ste2p undergoes …