Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Multiple myeloma is a plasma cell malignancy almost always preceded by precursor
conditions, but low tumor burden of these early stages has hindered the study of their …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Focalized proteolysis by invasive cells is essential for the remodeling of ECM in multiple
physiological processes, including bone resorption, immune surveillance, and organ …

As the indispensable second cellular messenger, calcium signaling is involved in the
regulation of almost all physiological processes by activating specific target proteins. The …

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer
development such as cell cycle progression and cellular migration. Receptor-regulated …

The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators
of cell function; therefore, calcium as a universal intracellular mediator is involved in very …

In recent decades, medical research has been primarily focused on the inherited aspect of
cancers, despite the reality that only 5–10% of tumours discovered are derived from genetic …

Objective: The migration and invasion features, which were associated with inflammatory
response, acted as vital roles in the development of colon cancer. Quercetin, a bioflavonoid …