Obesity, neuroinflammation, and reproductive function

NM Lainez, D Coss - Endocrinology, 2019 - academic.oup.com
The increasing occurrence of obesity has become a significant public health concern.
Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis …

High-fat diet and female fertility

NM Hohos, ME Skaznik-Wikiel - Endocrinology, 2017 - academic.oup.com
The prevalence of obesity is high among reproductive-age women and is associated with
impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity …

Diet-induced obesity elicits macrophage infiltration and reduction in spine density in the hypothalami of male but not female mice

NM Lainez, CR Jonak, MG Nair, IM Ethell… - Frontiers in …, 2018 - frontiersin.org
Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice
are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic …

Obesity alters POMC and kisspeptin neuron cross talk leading to reduced luteinizing hormone in male mice

PA Villa, RE Ruggiero-Ruff, BB Jamieson… - Journal of …, 2024 - jneurosci.org
Obesity is associated with hypogonadism in males, characterized by low testosterone and
sperm number. Previous studies determined that these stem from dysregulation of …

High-fat diet and female fertility across lifespan: a comparative lesson from mammal models

C Di Berardino, A Peserico, G Capacchietti… - Nutrients, 2022 - mdpi.com
Female reproduction focuses mainly on achieving fully grown follicles and competent
oocytes to be successfully fertilized, as well as on nourishing the develo** offspring once …

Pathophysiology of obesity-related infertility and its prevention and treatment by potential phytotherapeutics

VVS Uddandrao, P Brahma Naidu… - International Journal of …, 2024 - nature.com
Background Obesity is a complex multifactorial disease in which the accumulation of excess
body fat has adverse health effects, as it can increase the risk of several problems, including …

Sex-and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression

S Adams, K Wiersielis, A Yasrebi, K Conde… - Reproductive …, 2020 - Elsevier
After the phase-out of polybrominated diphenyl ethers, their replacement compounds,
organophosphate flame retardants (OPFRs) became ubiquitous in home and work …

High‐refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats

OMS Niño, CS da Costa, KM Torres, JF Zanol… - Toxicology Letters, 2020 - Elsevier
Obesity is associated with several female reproductive complications, such as polycystic
ovary syndrome (PCOS). The exact mechanism of this relationship remains unclear. Few …

Transcriptomic analysis reveals endometrial dynamics in normoweight and overweight/obese polycystic ovary syndrome women

S Liu, L Hong, R Lian, S **ao, Y Li, L Diao… - Frontiers in …, 2022 - frontiersin.org
The aim of this work was to identify the transcriptomic characteristics of the endometrium in
normoweight and overweight/obese polycystic ovary syndrome (PCOS) potentially …

Impact of elastin-derived VGVAPG peptide on bidirectional interaction between peroxisome proliferator-activated receptor gamma (Pparγ) and beta-galactosidase (β …

KA Szychowski, J Gmiński - Naunyn-Schmiedeberg's Archives of …, 2019 - Springer
The process of degradation of the elastin-rich extracellular matrix produces elastin-derived
peptides (EDPs). Different types of EDPs are detectable in the cerebrospinal fluid in healthy …