Various chemicals found in the human and wildlife environments have the potential to
disrupt endocrine functions in exposed organisms. Increasingly, the enzymes involved in the …

The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids,
glucocorticoids and adrenal androgens. These steroids arise from morphologically and …

Various pesticides known or suspected to interfere with steroid hormone function were
screened in H295R cells for effects on catalytic activity and mRNA expression of aromatase …

There is increasing concern that certain chemicals in the environment can cause endocrine
disruption in exposed humans and wildlife. Investigations of potential effects on endocrine …

Male and female external genitalia appear identical early in gestation. Testosterone
exposure at 8–12 weeks' gestation causes male differentiation. Female fetuses virilize if their …

The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids,
glucocorticoids and adrenal androgens. These steroids arise from morphologically and …

Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular
volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

The human adrenal cortex secretes mineralocorticoids, glucocorticoids and adrenal
androgens. These steroids are produced from unique cell types located within the three …

To identify and prioritize chemicals that may alter steroidogenesis, an in vitro screening
assay based on measuring alterations in hormone production was developed using the …