While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Exosomes are tiny vesicles (30–150 nm) constantly secreted by all healthy and abnormal
cells, and found in abundance in all body fluids. These vesicles, loaded with unique RNA …

The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and the
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …

MicroRNAs (miRNAs) are a class of small (∼ 22 nucleotides) noncoding RNAs involved in
the regulation of gene expression at the post‐translational level. It is estimated that 30–90 …

It is generally considered that Parkinson's disease is induced by specific agents that
degenerate a clearly defined population of dopaminergic neurons. Data commented in this …