Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Several reactions in biological systems contribute to maintain the steady-state
concentrations of superoxide anion (O 2⨪) and hydrogen peroxide (H 2 O 2). The electron …

The voltage-dependent anion channel (VDAC) mediates trafficking of small molecules and
ions across the eukaryotic outer mitochondrial membrane. VDAC also interacts with …

The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the
most abundant protein in the mitochondrial outer membrane (MOM). VDAC is the channel …