Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost
all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of …

The molecular and cellular processes that lead to renal damage and to the heterogeneity of
lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing …

Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Epithelial–mesenchymal transition is an indispensable mechanism during morphogenesis,
as without mesenchymal cells, tissues and organs will never be formed. However, epithelial …

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells
found in complex tissues. This dynamic process helps organize the formation of the body …

Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver.
While some view fibroblasts in adult tissues as nothing more than primitive mesenchymal …

Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …

Fibroblasts are one of the most abundant cell types in connective tissues. These cells are
responsible for tissue homeostasis under normal physiological conditions. When tissues are …

Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …