Depression is a growing pandemic in developed societies. The use of inbred mouse strains
in pre-clinical psychiatric research has proven to be a valuable resource. Firstly, they …

Gene modification technologies play a vital role in the study of biological systems and
pathways. Although there is widespread and beneficial use of genetic mouse models …

Cellular stress, particularly in response to toxic and metabolic insults that perturb function of
the endoplasmic reticulum (ER stress), is a powerful inducer of the transcription factor …

Strains of mice that show characteristic patterns of behavior are critical for research in
neurobehavioral genetics. Possible confounding influences of the laboratory environment …

Mutations in the human parkin gene cause autosomal recessive juvenile parkinsonism, a
heritable form of Parkinson's disease (PD). To determine whether mutations in the mouse …

Locomotor activity is a polygenic trait that varies widely among inbred strains of mice. To
characterize the role of D2 dopamine receptors in locomotion, we generated F2hybrid …

Most inbred laboratory mouse strains are known to have originated from a mixed but limited
founder population in a few laboratories,. However, the effect of this breeding history on …

The high degree of similarity between the mouse and human genomes is demonstrated
through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained …

To determine the genetic causes and molecular mechanisms responsible for
neurobehavioral differences in mice, we used highly parallel gene expression profiling to …

A set of 1638 informative SNP markers easily assayed by the Amplifluor genoty** system
were tested in 102 mouse strains, including the majority of the common and wild-derived …