Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

Arrhythmogenic cardiomyopathy (ACM) is a familial, nonischemic heart disease typically
inherited via an autosomal dominant pattern (Nava et al.,[1]; Wlodarska et al.,[2]). Often …

Traditional cardiomyopathy paradigms segregate inflammatory etiologies from those caused
by genetic variants. An identified or presumed trigger is implicated in acute myocarditis or …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are widely used
for disease modeling and pharmacological screening. However, their application has mainly …

Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …

Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes raise the possibility of
generating pluripotent stem cells from a wide range of human diseases. In the cardiology …

The development of atrial fibrillation (AF) is a highly complex, multifactorial process involving
pathophysiologic mechanisms, molecular pathway mechanisms and numerous genetic …

Arrhythmogenic cardiomyopathy (ACM) is a rare genetic disease associated with ventricular
arrhythmias in patients. The occurrence of these arrhythmias is due to direct …

Genetic variants in gene-encoding proteins involved in cell–cell connecting structures, such
as desmosomes and gap junctions, may cause a skin and/or cardiac phenotype, of which …

Cardiomyopathy is a pathological condition characterized by cardiac pump failure due to
myocardial dysfunction and the major cause of advanced heart failure requiring heart …