Motifs rich in arginines and glycines were recognized several decades ago to play functional
roles and were termed glycine-arginine-rich (GAR) domains and/or RGG boxes. We review …

Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it
plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus …

Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in
the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA …

Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …

RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of
cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated …

Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells
without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its …

A growing body of work demonstrates the importance of post-transcriptional control, in
particular translation initiation, in the overall regulation of gene expression. Here we focus …

Numerous studies have described the altered expression and the causal role of microRNAs
(miRNAs) in human cancer. However, to date, efforts to modulate miRNA levels for …

AUF1 is a family of four proteins generated by alternative pre-mRNA splicing that form high
affinity complexes with AU-rich, mRNA-destabilizing sequences located within the 3 …