While hydrogen plays an ever-increasing role in modern society, nature has utilized
hydrogen since a very long time as an energy carrier and storage molecule. Among the …

The reaction takes place at a specialized metal center that dramatically increases the acidity
of H2 and leads to a heterolytic splitting of the molecule which is strongly accelerated by the …

It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Abstract The [FeFe]-and [NiFe]-hydrogenases catalyze the formal interconversion between
hydrogen and protons and electrons, possess characteristic non-protein ligands at their …

Hydrogenases are metalloenzymes that are key to energy metabolism in a variety of
microbial communities. Divided into three classes based on their metal content, the [Fe] …

The precise electrochemical features of metal cofactors that convey the functions of redox
enzymes are essentially determined by the specific interaction pattern between cofactor and …

[FeFe]-Hydrogenases are complex metalloproteins that catalyze the reversible reduction of
protons to molecular hydrogen utilizing a unique diiron subcluster bridged to a [4Fe4S] …

Irreversible inhibition by molecular oxygen (O 2) complicates the use of [FeFe]-
hydrogenases (HydA) for biotechnological hydrogen (H 2) production. Modification by O 2 of …

Abstract Maturation of [FeFe]‐hydrogenase (HydA) involves synthesis of a CO, CN−, and
dithiomethylamine (DTMA)‐coordinated 2Fe subcluster that is inserted into HydA to make …

Hydrogen gas is used extensively in industry today and is often put forward as a suitable
energy carrier due its high energy density. Currently, the main source of molecular hydrogen …