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Therapeutic mechanisms of psychedelics and entactogens
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …
produce both rapid and sustained therapeutic effects across several indications. Currently …
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …
Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditions
M Alwindi, A Bizanti - Heliyon, 2023 - cell.com
Vesicular monoamine transporters (VMATs) are key regulators of neurotransmitter release
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback
Abstract Serotonin (5-HT) plays an essential role in reward processing, however, the
possibilities to investigate 5-HT action in humans during emotional stimulation are …
possibilities to investigate 5-HT action in humans during emotional stimulation are …
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
vesicular release to ensure temporal and spatial regulation of serotonergic signalling and …
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
P Puigseslloses, N Nadal-Gratacós, G Ketsela… - Molecular …, 2024 - nature.com
Recent studies have sparked renewed interest in the therapeutic potential of psychedelics
for treating depression and other mental health conditions. Simultaneously, the novel …
for treating depression and other mental health conditions. Simultaneously, the novel …
Electroacupuncture modulates glutamate neurotransmission to alleviate PTSD-like behaviors in a PTSD animal model
M Cai, HR Park, EJ Yang - Translational Psychiatry, 2023 - nature.com
Post-traumatic stress disorder (PTSD) is a mental disorder that develops after exposure to a
traumatic event. Owing to the relatively low rates of response and remission with selective …
traumatic event. Owing to the relatively low rates of response and remission with selective …
Structure–Activity Relationship of Synthetic Cathinones: An Updated Review
The escalating prevalence of new psychoactive substances (NPSs) poses a significant
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …
Direct serotonin release in humans shapes aversive learning and inhibition
The role of serotonin in human behaviour is informed by approaches which allow in vivo
modification of synaptic serotonin. However, characterising the effects of increased …
modification of synaptic serotonin. However, characterising the effects of increased …
Bioisosteric analogs of MDMA: Improving the pharmacological profile?
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re‐emerging in clinical settings as a
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …