CD48, a member of the signaling lymphocyte activation molecule family, participates in
adhesion and activation of immune cells. Although constitutively expressed on most …

Conspectus Optical imaging has become an essential tool to study biomolecular processes
in live systems with unprecedented spatial resolution. New fluorescent technologies and …

Revealing the molecular basis of virus-specific CD8 T cell exhaustion in chronic infections is
critical for the understanding of the disease pathogenesis and the designing of novel …

The SLAMF family (SLAMF) of cell surface glycoproteins is comprised of nine glycoproteins
and while SLAMF1, 3, 5, 6, 7, 8, and 9 are self-ligand receptors, SLAMF2 and SLAMF4 …

Summary Decreased HIV-specific CD8+ T cell proliferation is a hallmark of chronic infection,
but the mechanisms of decline are unclear. We analyzed gene expression profiles from …

Objective Engagement of signaling lymphocytic activation molecule family member 4
(SLAMF4; CD244, 2B4) by its ligand SLAMF2 (CD48) modulates the function and expansion …

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the
swine industry. Identification of host genetic factors that enable selection for improved …

Lysosomes are vital organelles in living cells, which have acidic environments (pH 4.0–5.0)
where macrobiomolecules and malfunctioning organelles are broken down into monomers …

Virus-specific T cells are critical in mediating the pathogenesis of hepatitis B virus (HBV)
infection. Interferon gamma (IFNγ)-producing T cells are associated with resolution; in …

The CD1d-restricted invariant natural killer T (iNKT) cells are implicated in innate immune
responses against human immunodeficiency virus (HIV). However, the determinants of …