Interferons (IFN) are potent biologically active proteins synthesised and secreted by somatic
cells of all mammalian species. They have been well characterised, especially those of …

Background The beneficial effects of interferon β have only been shown for patients in the
relapsing-remitting phase of multiple sclerosis (MS). The role of interferon β in the treatment …

The traditional antiviral assays for the determination of interferon potency are reported to
have considerable variability between and within assays. Although several reporter gene …

MxA gene expression is known to be regulated tightly and exclusively by type I interferons
(IFNs). The kinetics of MxA gene expression was analyzed in peripheral blood mononuclear …

Background Macrophages provide an interface between innate and adaptive immunity and
are important long-lived reservoirs for Human Immunodeficiency Virus Type-1 (HIV-1) …

We describe here a specific and sensitive assay for biologically active bovine type-I
interferon (IFN) in an Mx/CAT reporter gene assay. The assay is based on Madin–Darby …

An important aspect of gene transfer into farm animals is the improvement of disease
resistance. The mouse Mx1 protein is known to be sufficient to confer resistance to influenza …

Background We developed a novel intranasal influenza vaccine approach that is based on
the construction of replication-deficient vaccine viruses that lack the entire NS1 gene (ΔNS1 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes several host
proteases to cleave the spike (S) protein to enter host cells. SARS-CoV-2 S protein is …

The objective of this study was to explore the relationship between serum levels of β2-
microglobulin (β2MG), which some studies suggest reflect disease activity in systemic lupus …