Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Replication fork reversal safeguards genome integrity as a replication stress response. DNA
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …

Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that
uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single …

Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and
resistance to agents that damage DNA or collapse replication forks, presumably through …

Defects in DNA repair have been extensively linked to neurodegenerative diseases, but the
exact mechanisms remain poorly understood. We found that FUS, an RNA/DNA-binding …

The fidelity of genetic information is essential for cellular function and viability. DNA double-
strand breaks (DSBs) pose a significant threat to genome integrity, necessitating efficient …

Telomere length maintenance is a requisite feature of cellular immortalization and a
hallmark of human cancer. While most human cancers express telomerase activity,∼ 10 …

Characterizing the functional overlap and mutagenic potential of different pathways of
chromosomal double-strand break (DSB) repair is important to understand how mutations …

Chromosomal double strand breaks (DSBs) can be repaired by a number of mechanisms
that result in diverse genetic outcomes. To examine distinct outcomes of chromosomal DSB …