Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

The Polycomb repressive system is an essential chromatin-based regulator of gene
expression. Despite being extensively studied, how the Polycomb system selects its target …

Polycomb repressive complexes 1 and 2 (PRC1 and 2) are required for heritable repression
of developmental genes. The cis-and trans-acting factors that contribute to epigenetic …

Thousands of proteins localize to the nucleus; however, it remains unclear which contain
transcriptional effectors. Here, we develop HT-recruit, a pooled assay where protein libraries …

Organization of the genome into transcriptionally active euchromatin and silenced
heterochromatin is essential for eukaryotic cell function. Phase-separation has been …

Abstract The Polycomb group (PcG) protein Enhancer of Zeste Homolog 2 (EZH2) is one of
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …

Stable propagation of epigenetic information is important for maintaining cell identity in
multicellular organisms. However, it remains largely unknown how mono-ubiquitinated …

Abstract Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate
gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive …