What made sesquiterpene lactones reach cancer clinical trials?
A Ghantous, H Gali-Muhtasib, H Vuorela, NA Saliba… - Drug discovery today, 2010 - Elsevier
Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …
medicine against inflammation and cancer. This review focuses on the chemical and …
Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment
SA Jordan, DG Cunningham, RJ Marles - Toxicology and applied …, 2010 - Elsevier
Although herbal medicinal products (HMP) have been perceived by the public as relatively
low risk, there has been more recognition of the potential risks associated with this type of …
low risk, there has been more recognition of the potential risks associated with this type of …
Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities
Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum
parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a …
parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a …
Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB
B Siedle, AJ García-Piñeres, R Murillo… - Journal of medicinal …, 2004 - ACS Publications
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used
medicinal plants from the Asteraceae family. They are known to possess a considerable …
medicinal plants from the Asteraceae family. They are known to possess a considerable …
Fungicidal activity of natural and synthetic sesquiterpene lactone analogs
Fungicidal activity of 36 natural and synthetic sesquiterpene lactones with guaianolide,
trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide …
trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide …
Use of fingerprinting and marker compounds for identification and standardization of botanical drugs: strategies for applying pharmaceutical HPLC analysis to herbal …
NJ Lazarowych, P Pekos - Drug information journal: DIJ/Drug Information …, 1998 - Springer
For standardization of natural product drugs, single chemical entities,“marker
compounds,“may be used as potency standards in high performance liquid chromatography …
compounds,“may be used as potency standards in high performance liquid chromatography …
Sesquiterpene lactones: More than protective plant compounds with high toxicity
GF Padilla-Gonzalez, FA dos Santos… - Critical Reviews in …, 2016 - Taylor & Francis
Sesquiterpene lactones (STLs) constitute a large group of secondary metabolites that are
widely distributed in several angiosperm plant families and a few bryophytes, including …
widely distributed in several angiosperm plant families and a few bryophytes, including …
Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis
D Carlisi, G Buttitta, R Di Fiore, C Scerri… - Cell death & …, 2016 - nature.com
Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma
associated with a high rate of recidivism. In this paper, we report the production of …
associated with a high rate of recidivism. In this paper, we report the production of …
[BOOK][B] Herbal medicines in pregnancy and lactation: an evidence-based approach
Exposures to over-the-counter products are frequent in pregnant women. Perhaps this is a
paradoxical response to the decreased use of prescribed medications during pregnancy for …
paradoxical response to the decreased use of prescribed medications during pregnancy for …
The use of allelopathic studies in the search for natural herbicides
The use of herbicides is claimed to negatively affect the environment and actually it does not
represent an appropriate tool for the control of some weeds develo** resistance …
represent an appropriate tool for the control of some weeds develo** resistance …