Recent advances in our understanding of RNA biology have uncovered crucial roles for
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …

Neurotransmission between neurons, which can occur over the span of a few milliseconds,
relies on the controlled release of small molecule neurotransmitters, many of which are …

Specific molecular recognition is routine for biology, but has proved difficult to achieve in
synthetic systems. Carbohydrate substrates are especially challenging, because of their …

The expression of biological functions, such as enzyme catalysis, immune response, and
cargo transport in confined nanospaces, with very different physical and chemical …

The development of innovative methodologies to identify RNA binders has attracted
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …

During the last half a century, great achievements have been made in molecular recognition
in parallel with the invention of numerous synthetic receptors. However, the selective …

Motivated by their potential biological applications, anion receptors are increasingly
explored as transmembrane transporters for anions. The vast majority of the reported anion …

Understanding the fundamentals of natural design, structure, and function has pushed the
limits of current knowledge and has enabled us to transfer knowledge from the bench to the …

Buried salt bridges widely exist in protein structures but are rarely used in synthetic systems
for molecular recognition in water. By mimicking the binding pocket of bioreceptors, we …

Selective recognition of neutral hydrophilic molecules in water is a challenge for
supramolecular chemistry but commonplace in nature. By mimicking the binding pocket of …