The role of natural products in drug discovery and development against neglected tropical diseases
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in develo** …
more than 1 billion people annually, including 875 million children in develo** …
Natural product based leads to fight against leishmaniasis
The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …
Natural and synthetic coumarins as antileishmanial agents: A review
The neglected tropical disease leishmaniasis is still a major public health problem that
affects millions of people worldwide. Related to poor-living conditions, this vector-borne …
affects millions of people worldwide. Related to poor-living conditions, this vector-borne …
On the possibility of tuning molecular edges to direct supramolecular self-assembly in coumarin derivatives through cooperative weak forces: crystallographic and …
Four organic compounds based on substituted coumarin derivatives (1–4) have been
synthesized and characterized by X-ray structural studies with a detailed analysis of …
synthesized and characterized by X-ray structural studies with a detailed analysis of …
Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes
Two new sesquiterpene coumarins, named szowitsiacoumarin A (1) and szowitsiacoumarin
B (2), and a phenylpropanoid derivative, 2-epihelmanticine (3), together with nine known …
B (2), and a phenylpropanoid derivative, 2-epihelmanticine (3), together with nine known …
Antiplasmodial activity of coumarins isolated from Polygala boliviensis: in vitro and in silico studies
DF da Silva, JL de Souza, DM da Costa… - Journal of …, 2023 - Taylor & Francis
Polygala boliviensis is found in the Brazilian semiarid region. This specie is little chemically
and biologically studied. Polygala spp. have different metabolites, especially coumarins …
and biologically studied. Polygala spp. have different metabolites, especially coumarins …
A review on new natural and synthetic anti-leishmanial chemotherapeutic agents and current perspective of treatment approaches.
N Majumder, A Banerjee, S Saha - Acta Tropica, 2023 - Elsevier
Leishmaniases are considered among the most neglected yet dangerous parasitic diseases
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …
A review of the pharmacological and therapeutic effects of auraptene
There is a growing awareness in herbal medications as they are usually safe and devoid of
significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether …
significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether …
Discovering the structure–activity relationships of different O-prenylated coumarin derivatives as effective anticancer agents in human cervical cancer cells
Cervical cancer remains one of the greatest life threatening diseases for women worldwide.
Although chemotherapy is considered as a standard treatment for advanced cervical …
Although chemotherapy is considered as a standard treatment for advanced cervical …
In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon
MF Dolabela, SG Oliveira, JM Nascimento, JM Peres… - Phytomedicine, 2008 - Elsevier
Esenbeckia febrifuga (Rutaceae) is a plant traditionally used to treat malaria in the Brazilian
Amazon region. Ethanol extract of stems displayed a good antiplasmodial activity against …
Amazon region. Ethanol extract of stems displayed a good antiplasmodial activity against …