Immune ageing at single-cell resolution
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
some chronic, infectious and autoimmune diseases. In recent years, widespread application …
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review
Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved
ejection fraction (HFpEF), the most common form of heart failure among older individuals …
ejection fraction (HFpEF), the most common form of heart failure among older individuals …
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty
Frailty is an intermediate status of the human aging process, associated with
decompensated homeostasis and death. The immune phenotype of frailty and its underlying …
decompensated homeostasis and death. The immune phenotype of frailty and its underlying …
Successful and maladaptive T cell aging
Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …
fundamentally restructured immune system in older individuals. Here we review the cellular …
Human T cell immunosenescence and inflammation in aging
A Bektas, SH Schurman, R Sen… - Journal of leukocyte …, 2017 - Wiley Online Library
The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …
lead to the emergence of characteristic phenotypes, including increased susceptibility to …
Gene expression hallmarks of cellular ageing
Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …
The chromatin accessibility signature of human immune aging stems from CD8+ T cells
Aging is linked to deficiencies in immune responses and increased systemic inflammation.
To unravel the regulatory programs behind these changes, we applied systems immunology …
To unravel the regulatory programs behind these changes, we applied systems immunology …
Association between endometriosis and hypercholesterolemia or hypertension
An altered hormonal or chronic systemic inflammatory milieu characterizing endometriosis
may result in a higher risk of hypercholesterolemia and hypertension. Conversely, elevated …
may result in a higher risk of hypercholesterolemia and hypertension. Conversely, elevated …
Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective
The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …
Production of MHCII‐expressing classical monocytes increases during aging in mice and humans
Aging is associated with increased monocyte production and altered monocyte function.
Classical monocytes are heterogenous and a shift in their subset composition may underlie …
Classical monocytes are heterogenous and a shift in their subset composition may underlie …