Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer
H Azam, L Pierro, M Reina, WM Gallagher… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction The Serum Response Factor (SRF) is a transcription factor involved
in three hallmarks of cancer: the promotion of cell proliferation, cell death resistance and …
in three hallmarks of cancer: the promotion of cell proliferation, cell death resistance and …
Prostate cancer progression relies on the mitotic kinase citron kinase
Prostate cancer remains the second leading cause of cancer death in men in Western
cultures. A deeper understanding of the mechanisms by which prostate cancer cells divide …
cultures. A deeper understanding of the mechanisms by which prostate cancer cells divide …
SRF inhibitors reduce prostate cancer cell proliferation through cell cycle arrest in an isogenic model of castrate-resistant prostate cancer
H Azam, S Maher, S Clarke, WM Gallagher… - Cell Cycle, 2023 - Taylor & Francis
Castrate-resistant prostate cancer (CRPC) is challenging to treat, despite improvements with
next-generation anti-androgens such as enzalutamide, due to acquired resistance. One of …
next-generation anti-androgens such as enzalutamide, due to acquired resistance. One of …
Exploration of prognostic biomarkers and therapeutic targets in the microenvironment of bladder cancer based on CXC chemokines
X Sun, Q Chen, L Zhang, J Chen, X Zhang - 2021 - researchsquare.com
Bladder cancer (BLCA) has a high rate of morbidity and mortality, and is considered as one
of the most malignant tumors of the urinary system. Tumor cells interact with surrounding …
of the most malignant tumors of the urinary system. Tumor cells interact with surrounding …
AR-dependent phosphorylation and phospho-proteome targets in prostate cancer
Prostate cancer (CaP) is the second leading cause of cancer-related deaths in western men.
Because androgens drive CaP by activating the androgen receptor (AR), blocking AR's …
Because androgens drive CaP by activating the androgen receptor (AR), blocking AR's …
Exosome-derived miRNAs as potential biomarkers for prostate bone metastasis
Z Lu, J Hou, X Li, J Zhou, B Luo, S Liang… - … Journal of General …, 2022 - Taylor & Francis
Purpose The purpose of this study was to identify the potential exosome-derived microRNAs
(miRNAs) related to prostate cancer (Pca) bone metastasis. Methods Two datasets were …
(miRNAs) related to prostate cancer (Pca) bone metastasis. Methods Two datasets were …
Screening of Specific and Common Pathways in Breast Cancer Cell Lines MCF-7 and MDA-MB-231 Treated with Chlorophyllides Composites
KS Huang, YT Wang, O Byadgi, TY Huang, MH Tai… - Molecules, 2022 - mdpi.com
Our previous findings have shown that the chlorophyllides composites have anticancer
activities to breast cancer cell lines (MCF-7 and MDA-MB-231). In the present study …
activities to breast cancer cell lines (MCF-7 and MDA-MB-231). In the present study …
Identification of druggable targets from the interactome of the Androgen Receptor and Serum Response Factor pathways in prostate cancer
Background The Androgen Receptor (AR) pathway is crucial in driving the progression of
prostate cancer (PCa) to an advanced state. Despite the introduction of second-generation …
prostate cancer (PCa) to an advanced state. Despite the introduction of second-generation …
Characterization of Kinase Expression Related to Increased Migration of PC-3M Cells Using Global Comparative Phosphoproteome Analysis
Y Gao, YS Ha, TG Kwon, YC Cho… - Cancer Genomics & …, 2020 - cgp.iiarjournals.org
Background/Aim: Prostate cancer (PCa) is the second-most commonly occurring cancer
among men, worldwide. Although the mechanisms associated with the progression of …
among men, worldwide. Although the mechanisms associated with the progression of …
[BOOK][B] PKN1 is a novel therapeutic target to block serum response factor-dependent androgen receptor action in advanced prostate cancer
VB Venkadakrishnan - 2020 - search.proquest.com
Prostate cancer (CaP) accounts for more than 30,000 deaths annually in the United States.
Sustained reliance on androgen receptor (AR) after failure of AR-targeting androgen …
Sustained reliance on androgen receptor (AR) after failure of AR-targeting androgen …