The explosive growth of biomedical Big Data presents both significant opportunities and
challenges in the realm of knowledge discovery and translational applications within …

Combination therapy has shown an obvious efficacy on complex diseases and can greatly
reduce the development of drug resistance. However, even with high-throughput screens …

Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to
human health. This is compounded by the limited efficacy of available treatments and high …

Polypharmacology drugs—compounds that inhibit multiple proteins—have many
applications but are difficult to design. To address this challenge we have developed …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …

Abstract Analysis across a growing number of single-cell perturbation datasets is hampered
by poor data interoperability. To facilitate development and benchmarking of computational …

Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a popular chemical information
resource that serves a wide range of use cases. In the past two years, a number of changes …

There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …

Statistical methods for enrichment analysis are important tools to extract biological
information from omics experiments. Although these methods have been widely used for the …