[HTML][HTML] PPARs as metabolic sensors and therapeutic targets in liver diseases

HC Monroy-Ramirez, M Galicia-Moreno… - International journal of …, 2021 - mdpi.com
Carbohydrates and lipids are two components of the diet that provide the necessary energy
to carry out various physiological processes to help maintain homeostasis in the body …

The role of glypican-3 in regulating Wnt, YAP, and hedgehog in liver cancer

A Kolluri, M Ho - Frontiers in oncology, 2019 - frontiersin.org
Glypican-3 (GPC3) is a cell-surface glycoprotein consisting of heparan sulfate
glycosaminoglycan chains and an inner protein core. It has important functions in cellular …

Host transcription factors in hepatitis B virus RNA synthesis

KL Turton, V Meier-Stephenson, MD Badmalia… - Viruses, 2020 - mdpi.com
The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one
of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due …

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

X Cheng, T Uchida, Y **a, R Umarova, CJ Liu… - The Journal of Clinical …, 2020 - jci.org
In patients with HBV and HCV coinfection, HBV reactivation leading to severe hepatitis has
been reported with the use of direct-acting antivirals (DAAs) to treat HCV infection. Here we …

Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infection

Y Teng, Z Xu, K Zhao, Y Zhong, J Wang, L Zhao… - Journal of …, 2021 - Elsevier
Background & Aims Our understanding of the interactions between HBV and its host cells is
still quite limited. Spliceosome associated factor 1 (SART1) has recently been found to …

Bioinformatics analyses of potential miRNA-mRNA regulatory axis in HBV-related hepatocellular carcinoma

DP Huang, YH Zeng, WQ Yuan… - … Journal of Medical …, 2021 - pmc.ncbi.nlm.nih.gov
Aims: We aimed to explore the crucial miRNA-mRNA axis through bioinformatics analysis
and provide evidences for the development of pathophysiological mechanisms and new …

A novel lncRNA IHS promotes tumor proliferation and metastasis in HCC by regulating the ERK-and AKT/GSK-3β-signaling pathways

Z Chen, W Yu, Q Zhou, J Zhang, H Jiang, D Hao… - … therapy Nucleic acids, 2019 - cell.com
Long noncoding RNAs (lncRNAs) are involved in a variety of biological processes such as
tumor proliferation and metastasis. A close relationship between hepatitis B virus X protein …

Hepatitis B surface antigen activates unfolded protein response in forming ground glass hepatocytes of chronic hepatitis B

Y Li, Y **a, X Cheng, DE Kleiner, SM Hewitt, J Sproch… - Viruses, 2019 - mdpi.com
Ground glass hepatocytes (GGHs), a histological hallmark of chronic hepatitis B virus (HBV)
infection, contain excessive hepatitis surface antigen (HBsAg) in the endoplasmic reticulum …

[PDF][PDF] Multiple roles for hepatitis B and C viruses and the host in the development of hepatocellular carcinoma

KJ Wangensteen, KM Chang - Hepatology, 2021 - Wiley Online Library
Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause persistent liver injury and
regenerative responses that can progress to liver cirrhosis and hepatocellular carcinoma …

Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis

M **e, H Guo, G Lou, J Yao, Y Liu, Y Sun… - Journal of Cellular …, 2021 - Wiley Online Library
Hepatitis B virus (HBV) infection is a major public health problem. The high levels of HBV
DNA and HBsAg are positively associated with the development of secondary liver …