Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …

DNA repair is a system of defenses designed to protect the integrity of the genome.
Deficiencies in this system likely lead to the development of cancer. The epidemiology of …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

Despite overwhelming evidence of tobacco's harmful effects and pressure from anti-smoking
advocates, current surveys show that about one-quarter of all adults in the United States are …

Background Incidence and survival trends of head and neck squamous cell carcinoma
(HNSCC) are essential knowledge for guiding policy making and research. Methods The …

Oral cancer incidence rates rose dramatically during the twentieth century in the United
States and Europe, especially among individuals under the age of 60 years. Although …

Marijuana is the most commonly used illegal drug in the United States. In some subcultures,
it is widely perceived to be harmless. Although the carcinogenic properties of marijuana …

Background The improvement in locoregional control of head and neck carcinomas over the
last decades does not appear to modify the final survival of these patients, mainly due to the …

The ability to metabolise carcinogens or pro-carcinogens, repair DNA damage, and control
cell signalling and the cell cycle are fundamental to homeostasis. Oral squamous cell …

In several countries, increased incidence of squamous cell carcinoma (SCC) of the tongue
in young adults has been suspected during the last decades. Some reports indicate a lower …